Arbutin imatha kuchotsedwa mwachilengedwe ku zomera monga bearberry ndikupangidwa ndi mankhwala. Synthesized Arbutin pakadali pano ndi imodzi mwazinthu zomwe zimagwiritsidwa ntchito kwambiri popanga zodzoladzola za hypopigmenting. Arbutin imathanso kunyowetsa khungu lomwe limawoneka ngati lopepuka kwambiri, chifukwa chake arbutin amagwiritsidwa ntchito zowunikira komanso zoyera muzodzola.

Arbutin imaphatikizapo Alpha-Arbutin ndi Beta-Arbutin. Kuti mudziwe zambiri zamalonda, mutha kuchezera ulalo: /alpha-arbutin-chinthu/

Zofunika Zaumisiri:

Zifukwa za pigmentation:

Mtundu wa khungu umatsimikiziridwa ndi kuyanjana kwa mitundu yosiyanasiyana. Mtundu wa bulauni umachokera ku ma eumelanin ndi phaeomelanin, omwe amapangidwa m'maselo apadera a epidermal otchedwa melanocytes. Enzyme tyrosinase, yomwe nthawi zambiri imakhala yosagwira ntchito, imapangidwa m'ma melanocyte awa. Kuyatsa kwake ndi kuwala kwa UV kumayambitsa melanogenesis, zovuta zingapo zamakina amtundu wa enzymatic zomwe zimadzetsa kupanga ma melanin, zomwe zimapangitsa kuti khungu likhale losawoneka bwino lomwe limawonekera ngati mawanga azaka, melasma kapena mabala.

Njira Yochitira:
Arbutin ndi glycosylated hydroquinone yomwe imabwera mumitundu iwiri, Alpha-Arbutin ndi Beta-Arbutin. Arbutins amaonedwa kuti ndi njira yabwino yowunikira khungu chifukwa imathandizira kutsekereza epidermal melanin biosynthesis. Zimathandiza kutsekereza epidermal melanin biosynthesis poletsa enzymatic oxidation ya Tyrosine ndi Dopa.

Alpha-Arbutin yatsimikiziridwa kuti ili ndi zotsatira zabwino kwambiri, ngakhale poyerekeza ndi mamolekyu ofanana ndi mankhwala, hydroquinone ndi beta-arbutin. Kuphatikiza pakuchita bwino kwambiri, imakhalanso ndi mbiri yabwino yachitetezo poyerekeza ndi hydroquinone, ndipo imakhala yokhazikika poyerekeza ndi beta-arbutin. Makhalidwe amenewa amapangitsa kuti khungu likhale lolimba komanso kuchepetsa mawanga akuda pakhungu.

Hydroquinone vs Alpha Arbutin
Hydroquinone yakhala ikuwoneka ngati muyezo wagolide wochizira hyperpigmentation. Ngakhale maphunziro azachipatala akuwonetsa mayankho abwino kwambiri a depigmentation opangidwa ndi 2% hydroquinone, zawonetsedwanso kuti zimayambitsa zovuta zoyipa. Izi ndi monga exogenous ochronosis, ng'ala, pigmented colloid milia, sclera, ndi misomali pigmentation, kutayika kwa khungu, kuwonongeka kwa chilonda ndikutulutsa fungo loyipa la nsomba. Hydroquinone imathanso kuwononga DNA. Zotsatira zoyipa izi zimachepetsa kugwiritsa ntchito hydroquinone.

Alpha-Arbutin yatsimikiziridwa kuti imawunikira kwambiri popanda poizoni ndi zokwiyitsa zomwe zimagwirizanitsidwa ndi hydroquinone.

Zinthu zosamalira khungu zomwe zili ndi arbutin:Skin Cream, Freckle Cream, Superior Pearl Cream ndi Facial Mask.